Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 20/20 | 1.00 |
| ▸ | EDNRA | P25101 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14289233 | 0.94 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL14289225 | 0.92 | EDNRB (0.85) | EDNRBEDNRA | |
| SCHEMBL14289224 | 0.90 | EDNRB (0.82) | EDNRBEDNRA | |
| SCHEMBL14289235 | 0.86 | EDNRB (0.86) | EDNRBEDNRA | |
| SCHEMBL7479303 | 0.86 | EDNRA (0.84) | EDNRBEDNRA | |
| SCHEMBL7483156 | 0.86 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL14289226 | 0.85 | EDNRA (0.84) | EDNRBEDNRA | |
| SCHEMBL14380540 | 0.85 | EDNRB (0.90) | EDNRBEDNRA | |
| SCHEMBL14289234 | 0.84 | EDNRB (0.84) | EDNRBEDNRA | |
| SCHEMBL7483162 | 0.83 | EDNRB (0.74) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465875-B1 | NOVEL ALKANSULFONAMIDES AS ENDOTHELIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-12-19 | — | — | EP | claimed |
| US-7323465-B2 | Alkansulfonamides as endothelin antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-01-29 | — | — | US | disclosed |
| US-7323465-B2 | Alkansulfonamides as endothelin antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-01-29 | — | — | US | disclosed |