Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.57 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 13/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848196 | 0.91 | PIK3CA (0.58) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL10328284 | 0.84 | PIK3CA (0.69) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL13848164 | 0.82 | PIK3CG (0.60) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL13848234 | 0.81 | PIK3CA (0.57) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL4125340 | 0.79 | PIK3CA (0.60) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL13848133 | 0.78 | PIK3CA (0.65) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL10327936 | 0.78 | PIK3CA (0.65) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL10327966 | 0.78 | PIK3CA (0.84) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL10327693 | 0.78 | PIK3CA (0.61) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD | |
| SCHEMBL13848112 | 0.77 | PIK3CA (0.60) | PIK3CAMAP3K12PIK3R1PIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |