Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.60 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327818 | 0.90 | PIK3CA (0.56) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL15334724 | 0.85 | PIK3CA (0.54) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL10327867 | 0.84 | PIK3CA (0.61) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL10327709 | 0.84 | PIK3CA (0.76) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4125040 | 0.83 | PIK3CA (0.69) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4120917 | 0.83 | LMNA (0.48) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL10327613 | 0.82 | PIK3CA (0.52) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL3990409 | 0.81 | PIK3CA (0.58) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL13848126 | 0.81 | PIK3CA (0.56) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4114468 | 0.80 | PIK3CA (0.54) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |