Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A3 | Q92570 | 1/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036784 | 0.88 | NR4A3 (0.74) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1905624 | 0.88 | NR4A3 (1.00) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4034195 | 0.86 | NR4A3 (0.80) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30153787 | 0.85 | NR4A3 (0.78) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19902355 | 0.83 | MAPK1 (0.69) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1907312 | 0.82 | NR4A3 (0.74) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20250838 | 0.82 | NR4A3 (0.56) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13887595 | 0.81 | NR4A3 (0.72) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14310927 | 0.79 | MAPT (0.74) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3715104 | 0.79 | SLC9A1 (0.70) | NR4A3MAPK1ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725544-B1 | 3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2009-05-27 | — | — | EP | disclosed |