Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AOC2 | O75106 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20417810 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1HTTALOX15ATM | |
| SCHEMBL25262162 | 0.79 | PTGS2 (0.50) | SMN1; SMN2ALDH1A1HTTALOX15ATM | |
| SCHEMBL1106467 | 0.77 | KDM4E (0.39) | ALDH1A1PTGS2ACACBAOC2MAPK1 | |
| SCHEMBL25160763 | 0.76 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1HTTALOX15ATM | |
| SCHEMBL12890143 | 0.75 | PTGS2 (0.41) | ALDH1A1HTTPTGS2ACACBAOC2 | |
| SCHEMBL11317932 | 0.75 | PTGS2 (0.49) | SMN1; SMN2ALDH1A1HTTALOX15PTGS2 | |
| SCHEMBL17014807 | 0.75 | PTGS2 (0.38) | ALDH1A1PTGS2ACACBMAPK1TDP1 | |
| SCHEMBL589332 | 0.75 | PTGS2 (0.38) | PTGS2ACACBAOC2 | |
| SCHEMBL17014806 | 0.75 | PTGS2 (0.41) | PTGS2ACACBAOC2ADORA2AADORA1 | |
| SCHEMBL20754670 | 0.75 | PTGS2 (0.35) | PTGS2ACACBAOC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136634-A1 | FUSED HETEROCYCLIC COMPOUNDS AS SELECTIVE BMP INHIBITORS | VANDERBILT UNIVERSITY (US) | 2018-07-26 | — | — | WO | disclosed |
| US-20090131370-A1 | Novel Nucleoside Derivatives | METABASIS THERAPEUTICS , INC. (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131370-A1 | Novel Nucleoside Derivatives | SLC29A1, SLC29A2, PNP | SMN1; SMN2 1490/4885ALDH1A1 1260/4885HTT 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.