Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | RAD52 | P43351 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.52 |
| ▸ | GFER | P55789 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10036440 | 0.85 | MAPT (0.52) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL24301307 | 0.85 | MAPT (0.52) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL156279 | 0.84 | MAPT (0.96) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL29507813 | 0.84 | MAPT (0.96) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL2306566 | 0.81 | ALDH1A1 (0.69) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL187881 | 0.80 | ALDH1A1 (0.71) | MAPTKDM4ERAD52ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL11751688 | 0.80 | MAPT (0.72) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL29477783 | 0.80 | ALDH1A1 (0.71) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL30600570 | 0.79 | MAPT (0.87) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL15961335 | 0.79 | MAPT (0.65) | MAPTKDM4ERAD52ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022041491-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE TARGETING EGFR MUTATION, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川大学华西医院 | 2022-03-03 | — | — | WO | disclosed |
| US-20090124605-A1 | Pyrazolo-Quinazoline Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-05-14 | — | — | US | disclosed |
| US-7482354-B2 | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124605-A1 | Pyrazolo-Quinazoline Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors | MAP3K5, MAP3K9, MAP4K2 | MAPT 2491/4885KDM4E 1015/4885RAD52 4168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.