⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768802 | 0.70 | MAPK1 (0.32) | — | |
| SCHEMBL822679 | 0.69 | — | — | |
| SCHEMBL14239696 | 0.67 | — | — | |
| SCHEMBL3687414 | 0.67 | — | — | |
| SCHEMBL23507215 | 0.66 | MAPK1 (0.58) | — | |
| SCHEMBL10487046 | 0.66 | MAPK1 (0.58) | — | |
| SCHEMBL14756121 | 0.63 | — | — | |
| SCHEMBL13274595 | 0.63 | CDK2 (0.35) | — | |
| SCHEMBL11299278 | 0.62 | — | — | |
| SCHEMBL17770651 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222868-A1 | Indazole Derivatives as Modulators of TNF Activity | UCB PHARMA S.A. (BE) | 2018-08-09 | — | — | US | disclosed |
| US-9932334-B2 | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-04-03 | — | — | US | disclosed |
| US-9932343-B2 | Fused tricyclic benzimidazoles derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-04-03 | — | — | US | disclosed |
| US-9890174-B2 | Fused Tricyclic imidazole derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-02-13 | — | — | US | disclosed |
| US-9714251-B2 | Imidazotriazine derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2017-07-25 | — | — | US | disclosed |
| US-20170129883-A1 | Tetrahydroimidazopyridine Derivatives as Modulators of TNF Activity | UCB BIOPHARMA SPRL (BE) | 2017-05-11 | — | — | US | disclosed |
| US-20160376276-A1 | Imidazotriazine Derivatives as Modulators of TNF Activity | UCB BIOPHARMA SPRL (BE) | 2016-12-29 | — | — | US | disclosed |
| US-9475820-B2 | Substituted imidazo[1,2-a]pyrazines as TNF activity modulators | UCB BIOPHARMA SPRL (BE) | 2016-10-25 | — | — | US | disclosed |
| US-20160304523-A1 | Fused Tricyclic Benzimidazoles Derivatives As Modulators of TNF Activity | SANOFI (FR) | 2016-10-20 | — | — | US | disclosed |
| US-20160304530-A1 | Fused Tricyclic Imidazole Derivatives As Modulators of TNF Activity | UCB PHARMA S.A. (BE) | 2016-10-20 | — | — | US | disclosed |
| US-20150191482-A1 | Imidazopyrazine Derivatives as Modulators of TNF Activity | UCB BIOPHARMA SPRL (BE) | 2015-07-09 | — | — | US | disclosed |
| US-20090124669-A1 | Structural Analogues of Avenanthramides, Their Use in Compositions Useful in the Treatment of Dermatological Disorders | RELIVIA S.R.L | 2009-05-14 | — | — | US | disclosed |
| CN-1081641-C | Carbapenem derivatives and antimicrobials | MEIJI SEIKA KAISHA (JP) | 2002-03-27 | — | — | CN | disclosed |
| CN-1209810-A | Carbapenem derivative and antibacterial agent | MEIJI SEIKA KAISHA (JP) | 1999-03-03 | — | — | CN | disclosed |