Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13721332 | 0.92 | EGFR (0.50) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL13720446 | 0.89 | KDM4E (0.45) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL13720284 | 0.88 | EGFR (0.50) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL13720804 | 0.88 | EGFR (0.50) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL13720542 | 0.88 | KDM4E (0.45) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL13720642 | 0.87 | ABCB1 (0.48) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL13720857 | 0.86 | KDM4E (0.43) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL16155987 | 0.85 | PRMT1 (0.46) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL13720504 | 0.82 | KDM4E (0.48) | KDM4EHPGDKMT2AMEN1EGFR | |
| SCHEMBL13720678 | 0.82 | KDM4E (0.46) | KDM4EHPGDKMT2AMEN1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | claimed |
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | disclosed |