Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13721332 | 0.91 | EGFR (0.50) | CA2CA12CA1CA9AKR1B1 | |
| SCHEMBL13720284 | 0.89 | EGFR (0.50) | CA2CA12CA1CA9ALDH1A1 | |
| SCHEMBL13720542 | 0.87 | KDM4E (0.45) | PRMT1CA2CA12CA1CA9 | |
| SCHEMBL13720804 | 0.87 | EGFR (0.50) | CA2CA12CA1CA9ALDH1A1 | |
| SCHEMBL13720446 | 0.86 | KDM4E (0.45) | CA2CA12CA1CA9ALDH1A1 | |
| SCHEMBL13720857 | 0.86 | KDM4E (0.43) | CA2CA12CA1CA9ALDH1A1 | |
| SCHEMBL13858680 | 0.85 | KDM4E (0.45) | CA2CA12CA1CA9AKR1B1 | |
| SCHEMBL13720642 | 0.85 | ABCB1 (0.48) | CA2CA12CA1CA9ALDH1A1 | |
| SCHEMBL13720252 | 0.84 | KDM4E (0.41) | AKR1B1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13720767 | 0.82 | MAPK8 (0.42) | PRMT1CA2CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | claimed |
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | disclosed |