Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 2/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13859410 | 0.90 | ACP1 (0.35) | MAPK14BACE1ALDH1A1ACP1BACE2 | |
| SCHEMBL13859243 | 0.90 | MAPK14 (0.38) | MAPK14BACE1ALDH1A1ACP1BACE2 | |
| SCHEMBL13859336 | 0.90 | ACP1 (0.40) | MAPK14BACE1ACP1BACE2CTSD | |
| SCHEMBL13835606 | 0.89 | MAPK14 (0.42) | MAPK14BACE1ALDH1A1ACP1BACE2 | |
| SCHEMBL13835609 | 0.89 | MAPK14 (0.42) | MAPK14BACE1ALDH1A1ACP1BACE2 | |
| SCHEMBL13859183 | 0.88 | ACP1 (0.33) | MAPK14BACE1ALDH1A1ACP1BACE2 | |
| SCHEMBL13859337 | 0.85 | APP (0.34) | BACE1ACP1BACE2KMT2AMEN1 | |
| SCHEMBL1980433 | 0.82 | BACE1 (0.33) | BACE1 | |
| SCHEMBL13859465 | 0.82 | BACE1 (0.41) | BACE1BACE2CTSD | |
| SCHEMBL13836380 | 0.80 | BACE1 (0.40) | MAPK14BACE1ACP1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709992-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156284-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | WO | disclosed |