Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | ACP1 | P24666 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 4/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | BCR | P11274 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 2/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13835689 | 0.89 | BACE1 (0.38) | APPSYKACP1BACE1MAPT | |
| SCHEMBL13835686 | 0.89 | BACE1 (0.38) | APPSYKACP1BACE1MAPT | |
| SCHEMBL13858927 | 0.85 | MAPK14 (0.42) | APPACP1BACE1MEN1KMT2A | |
| SCHEMBL13859410 | 0.83 | ACP1 (0.35) | ACP1BACE1MAPTKDM4EMEN1 | |
| SCHEMBL13859243 | 0.83 | MAPK14 (0.38) | ACP1BACE1MAPTBACE2 | |
| SCHEMBL13859336 | 0.83 | ACP1 (0.40) | APPACP1BACE1BACE2 | |
| SCHEMBL13859183 | 0.81 | ACP1 (0.33) | ACP1BACE1MAPTKDM4ERAB9A | |
| SCHEMBL1980433 | 0.80 | BACE1 (0.33) | BACE1MAPT | |
| SCHEMBL13859465 | 0.80 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL13859496 | 0.78 | BACE2 (0.40) | BACE1IDH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709992-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156284-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | WO | disclosed |