Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.79 |
| ▸ | LCK | P06239 | 9/20 | 0.79 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.79 |
| ▸ | MAP4K2 | Q12851 | 8/20 | 0.79 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.79 |
| ▸ | CLK2 | P49760 | 7/20 | 0.79 |
| ▸ | RPS6KA3 | P51812 | 7/20 | 0.79 |
| ▸ | MET | P08581 | 7/20 | 0.79 |
| ▸ | PLK4 | O00444 | 7/20 | 0.79 |
| ▸ | MARK3 | P27448 | 7/20 | 0.79 |
| ▸ | AXL | P30530 | 7/20 | 0.79 |
| ▸ | BLK | P51451 | 7/20 | 0.79 |
| ▸ | LIMK1 | P53667 | 7/20 | 0.79 |
| ▸ | STK3 | Q13188 | 7/20 | 0.79 |
| ▸ | MARK2 | Q7KZI7 | 7/20 | 0.79 |
| ▸ | SLK | Q9H2G2 | 7/20 | 0.79 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.79 |
| ▸ | RET | P07949 | 6/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.79 |
| ▸ | FLT1 | P17948 | 6/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486611 | 0.88 | KDR (1.00) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL4472448 | 0.83 | KDR (0.80) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL3531078 | 0.82 | KDR (1.00) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL4477490 | 0.81 | KDR (0.81) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL14013968 | 0.80 | FGFR1 (1.00) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL22930440 | 0.79 | PIK3CD (0.57) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL29549786 | 0.79 | KDR (1.00) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL4485284 | 0.79 | KDR (0.76) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL17034036 | 0.79 | KDR (1.00) | KDRLCKMAP4K4MAP4K2CLK4 | |
| SCHEMBL4477679 | 0.79 | KDR (0.79) | KDRLCKMAP4K4MAP4K2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009065232-A1 | CANCER DIAGNOSTIC AND THERAPEUTIC METHODS THAT TARGET PLK4/SAK | UNIVERSITY HEALTH NETWORK (CA) | 2009-05-28 | — | — | WO | disclosed |