Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 1.00 |
| ▸ | RET | P07949 | 5/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 5/20 | 1.00 |
| ▸ | FLT1 | P17948 | 5/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 3/20 | 1.00 |
| ▸ | PDGFRA | P16234 | 3/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.64 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.64 |
| ▸ | PLK4 | O00444 | 5/20 | 0.64 |
| ▸ | MARK3 | P27448 | 5/20 | 0.64 |
| ▸ | AXL | P30530 | 5/20 | 0.64 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.64 |
| ▸ | CSNK1G2 | P78368 | 5/20 | 0.64 |
| ▸ | STK3 | Q13188 | 5/20 | 0.64 |
| ▸ | CAMK2G | Q13555 | 5/20 | 0.64 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.64 |
| ▸ | MARK2 | Q7KZI7 | 5/20 | 0.64 |
| ▸ | HIPK4 | Q8NE63 | 5/20 | 0.64 |
| ▸ | SLK | Q9H2G2 | 5/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17034036 | 1.00 | KDR (1.00) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL29550161 | 0.85 | KDR (1.00) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL17034041 | 0.85 | KDR (1.00) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL13861829 | 0.79 | KDR (0.79) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL4486611 | 0.78 | KDR (1.00) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL4721372 | 0.76 | PLK4 (0.89) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL17034055 | 0.76 | KDR (1.00) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL29549573 | 0.75 | KDR (1.00) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL17034027 | 0.75 | KDR (1.00) | KDRRETFGFR1FLT1PDGFRB | |
| SCHEMBL5478260 | 0.74 | PLK4 (1.00) | KDRRETFGFR1FLT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3112351-B1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-03-30 | — | — | EP | disclosed |