Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 6/20 | 0.52 |
| ▸ | CLK1 | P49759 | 4/20 | 0.52 |
| ▸ | MAP3K5 | Q99683 | 9/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | WNT1 | P04628 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3486095 | 0.85 | CLK2 (0.73) | CLK2CLK1MAP3K5MCHR1DYRK1A | |
| Hydrochloric Acid SCHEMBL3486014 | 0.84 | CLK2 (0.72) | CLK2CLK1MAP3K5DYRK1AHRH1 | |
| SCHEMBL3486108 | 0.82 | MAP3K5 (0.67) | CLK2CLK1MAP3K5DYRK1AHRH1 | |
| Hydrochloric Acid SCHEMBL3485471 | 0.82 | MAP3K5 (0.66) | CLK2CLK1MAP3K5DYRK1AHRH1 | |
| SCHEMBL17632607 | 0.74 | PIK3CA (0.44) | CLK2CLK1MAP3K5KDM4ENPC1 | |
| SCHEMBL3779466 | 0.68 | CYP2C9 (0.61) | KDM4ENPC1PKM | |
| SCHEMBL19296078 | 0.67 | LMNA (0.56) | MCHR1KDM4ENPC1PKM | |
| SCHEMBL3485541 | 0.67 | CLK2 (0.80) | CLK2CLK1MAP3K5DYRK1AHRH1 | |
| SCHEMBL17632835 | 0.66 | USP30 (0.51) | DYRK1AWNT1GSK3B | |
| SCHEMBL17632833 | 0.66 | USP30 (0.51) | DYRK1AWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058309-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-05-13 | — | — | EP | disclosed |