Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | USP8 | P40818 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436191 | 0.83 | AR (0.40) | ARSQORSRCEGLN2 | |
| SCHEMBL11938977 | 0.80 | KDM4E (0.44) | ARKDM4EUSP2ALDH1A1ALOX5AP | |
| SCHEMBL30513214 | 0.75 | AR (0.40) | ARKDM4EALDH1A1SQOREGFR | |
| SCHEMBL25233862 | 0.73 | SQOR (0.38) | ARKDM4EUSP2ALDH1A1SQOR | |
| SCHEMBL13862086 | 0.73 | AR (0.44) | ARKDM4EUSP2ALDH1A1SQOR | |
| SCHEMBL16689294 | 0.72 | SRC (0.41) | ARKDM4EUSP2ALDH1A1SRC | |
| SCHEMBL8438702 | 0.72 | RET (0.42) | ALDH1A1CFD | |
| SCHEMBL13876611 | 0.72 | MAOB (0.40) | ARKDM4EUSP2ALDH1A1 | |
| SCHEMBL25739767 | 0.72 | AR (0.40) | ARKDM4EUSP2ALDH1A1 | |
| SCHEMBL23914846 | 0.71 | AR (0.45) | ARKDM4EUSP2ALDH1A1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622912-B1 | 2-ALKYNYL-AND 2-ALKENYL-PYRAZOLO- [4,3-E ] -1,2,4-TRIAZOLO- [1,5-C] -PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2009-05-27 | — | — | EP | disclosed |