Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.30 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254710 | 0.88 | FGFR1 (0.81) | FGFR1ALDH1A1 | |
| SCHEMBL10044383 | 0.84 | FGFR1 (0.72) | FGFR1 | |
| SCHEMBL4570525 | 0.84 | FGFR1 (0.71) | FGFR1 | |
| SCHEMBL1105227 | 0.82 | FGFR1 (0.70) | FGFR1ALDH1A1TDP1EP300 | |
| SCHEMBL14308878 | 0.81 | FGFR1 (0.71) | FGFR1EP300 | |
| SCHEMBL24140186 | 0.80 | FGFR1 (0.68) | FGFR1 | |
| SCHEMBL24140143 | 0.80 | FGFR1 (0.68) | FGFR1 | |
| SCHEMBL24140174 | 0.80 | FGFR1 (0.68) | FGFR1 | |
| SCHEMBL23292842 | 0.79 | FGFR1 (0.68) | FGFR1 | |
| SCHEMBL24140146 | 0.79 | FGFR1 (0.66) | FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9303051-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2015-11-19 | — | — | US | disclosed |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8569321-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | FGFR1 2756/4885ALDH1A1 2151/4885TDP1 814/4885 |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | FGFR1 2756/4885ALDH1A1 2151/4885TDP1 814/4885 |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PIK3CA, PNP | FGFR1 2756/4885ALDH1A1 2151/4885TDP1 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.