Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22026802 | 0.92 | ACE (0.52) | RENATMACEMAPK1CTSS | |
| SCHEMBL13323707 | 0.92 | ACE (0.52) | RENATMACEMAPK1CTSS | |
| SCHEMBL25728666 | 0.90 | REN (0.56) | RENATMACEMAPK1CTSS | |
| SCHEMBL30022871 | 0.87 | ACE (0.54) | RENATMACEMAPK1CTSS | |
| SCHEMBL13323705 | 0.84 | REN (0.50) | RENATMACEMAPK1CTSS | |
| SCHEMBL7323810 | 0.82 | ACE (0.56) | RENATMACECTSSCTSL | |
| SCHEMBL9659216 | 0.82 | ACE (0.56) | RENATMACECTSSCTSL | |
| SCHEMBL7323815 | 0.82 | ACE (0.56) | RENATMACECTSSCTSL | |
| SCHEMBL9659207 | 0.82 | ACE (0.56) | RENATMACECTSSCTSL | |
| SCHEMBL12137049 | 0.81 | ATM (0.61) | RENATMACECTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528174-B2 | Selective targeting agents for mitochondria | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-05-05 | — | — | US | disclosed |