Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.42 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30953155 | 1.00 | TDP1 (0.50) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL29739925 | 0.91 | TDP1 (0.50) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL432601 | 0.91 | TDP1 (0.50) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL29580289 | 0.89 | TDP1 (0.52) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL14578462 | 0.89 | TDP1 (0.52) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL123793 | 0.89 | TDP1 (0.52) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL9694173 | 0.87 | TSHR (0.50) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL45486 | 0.84 | TDP1 (0.60) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL30434858 | 0.83 | TDP1 (0.50) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL8967138 | 0.83 | TDP1 (0.50) | TDP1ATMALDH1A1HIF1AVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 201 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118955296-A | Method for preparing 2, 4-difluoroaniline and 2,3, 4-trifluoroaniline by using 3, 4-dichloronitrobenzene as raw material | 山东国邦药业有限公司 | 2024-11-15 | — | — | CN | claimed |
| CN-106573917-A | Method for synthesizing fluoroclozapine and derivatives thereof | 瓦伦帝克有限责任公司 | 2017-04-19 | — | — | CN | claimed |
| EP-0655997-B1 | PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME | ABBOTT LAB (US) | 1997-02-12 | — | — | EP | claimed |
| EP-0655997-A1 | PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME. | ABBOTT LAB (US) | 1995-06-07 | — | — | EP | claimed |
| EP-0562435-B1 | Process for the preparation of 3,5-difluoroaniline | HOECHST AG (DE) | 1995-06-07 | — | — | EP | claimed |
| EP-0655997-A4 | PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME. | ABBOTT LAB (US) | 1995-02-10 | — | — | EP | claimed |
| US-5294742-A | Process for preparing 3,5-difluoroaniline | HOECHST ATKIENGESELLSCHAFT (DE) | 1994-03-15 | — | — | US | claimed |
| US-5294721-A | Reacting a halonitrobenzene and a pyridinium salt | ABBOTT LABORATORIES (US) | 1994-03-15 | — | — | US | claimed |
| WO-1994004502-A1 | PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME | ABBOTT LABORATORIES (US) | 1994-03-03 | — | — | WO | claimed |
| EP-0562435-A1 | Process for the preparation of 3,5-difluoroaniline | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | claimed |
| US-4642399-A | REACTION OF CHLORONITRO BENZENE COMPOUNDS WITH FLUORIDE SALT | MALLINCKRODT, INC. (US) | 1987-02-10 | — | — | US | claimed |
| US-4418229-A | DISPLACEMENT OF CHLORONITROBENZENES WITH A FLUORIDE SALT, QUATERNARY AMMONIUM PHASE TRANSFER CATALYSTS | MALLINCKRODT, INC. (US) | 1983-11-29 | — | — | US | claimed |
| EP-0001825-B1 | METHOD OF PREPARING 2,4-DIFLUOROANILINE | MERCK & CO. INC. (US) | 1982-01-13 | — | — | EP | claimed |
| US-4294988-A | Method of preparing 2,4-difluoroaniline | MERCK & CO., INC. (US) | 1981-10-13 | — | — | US | claimed |
| EP-0001825-A1 | Method of preparing 2,4-difluoroaniline | MERCK & CO. INC. (US) | 1979-05-16 | — | — | EP | claimed |
| US-4140719-A | Solid-liquid phase transfer catalysis improved method of preparing 2,4-difluoroaniline | MERCK & CO., INC. (US) | 1979-02-20 | — | — | US | claimed |
| JP-6041026-A | — | — | None | — | — | JP | disclosed |
| US-12559492-B2 | BRAF degraders | C4 THERAPEUTICS, INC. (US) | 2026-02-24 | — | — | US | disclosed |
| US-4140719-A | Solid-liquid phase transfer catalysis improved method of preparing 2,4-difluoroaniline | MERCK & CO., INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4140719-A | Solid-liquid phase transfer catalysis improved method of preparing 2,4-difluoroaniline | MERCK & CO., INC. (US) | 1979-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12559492-B2 | BRAF degraders | BRAF, NRAS, HRAS | TDP1 1294/4885ATM 3560/4885ALDH1A1 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.