Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | PPP3CB | P16298 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13864551 | 0.94 | CYP3A4 (0.35) | CYP3A4ELANECTSBPPP3CBBIRC2 | |
| SCHEMBL13864478 | 0.90 | CYP3A4 (0.36) | CYP3A4ELANEKIF11KCNH2DHODH | |
| SCHEMBL7999134 | 0.89 | CYP3A4 (0.42) | CYP3A4ELANE | |
| SCHEMBL13864540 | 0.89 | CYP3A4 (0.35) | CYP3A4ELANEKIF11KCNH2DHODH | |
| SCHEMBL10261387 | 0.87 | CYP3A4 (0.34) | CYP3A4ELANEBIRC2 | |
| SCHEMBL10261079 | 0.87 | CYP3A4 (0.34) | CYP3A4ELANEBIRC2 | |
| SCHEMBL8014416 | 0.83 | CYP3A4 (0.33) | CYP3A4ELANE | |
| SCHEMBL8010213 | 0.83 | CYP3A4 (0.33) | CYP3A4ELANE | |
| SCHEMBL8008173 | 0.83 | MMP2 (0.32) | CYP3A4 | |
| SCHEMBL13864577 | 0.82 | ELANE (0.32) | CYP3A4ELANEKIF11KCNH2CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8951998-B2 | Quinoxaline-containing compounds as hepatitis C virus inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-8951998-B2 | Quinoxaline-containing compounds as hepatitis C virus inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-8324155-B2 | Quinoxaline-containing compounds as hepatitis C virus inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| WO-2009064975-A1 | QUINOXALINE-CONTAINING COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |