SCHEMBL1386492

SCHEMBL1386492

COCC1CN(Cc2ccc(-c3ccc(Cl)s3)cn2)CC(=O)N1Cc1cc2cnccc2[nH]1

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
F10 P00742 10/20 0.46
F2 P00734 2/20 0.36
PRMT5 O14744 1/20 0.30
WDR77 Q9BQA1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1385446 0.92 F10 (0.47) F10F2PRMT5WDR77
SCHEMBL1385010 0.88 F10 (0.46) F10F2PRMT5WDR77
SCHEMBL1384293 0.88 F10 (0.49) F10F2PRMT5WDR77
SCHEMBL27579289 0.85 F10 (0.41) F10F2
SCHEMBL1387140 0.81 F10 (0.63) F10F2PRMT5WDR77
SCHEMBL1385538 0.79 F10 (0.52) F10F2PRMT5WDR77
SCHEMBL1387055 0.78 F10 (0.39) F10F2
SCHEMBL27591289 0.78 F10 (0.43) F10F2PRMT5WDR77
SCHEMBL27591193 0.77 F10 (0.45) F10F2PRMT5WDR77
SCHEMBL27591185 0.77 F10 (0.42) F10F2PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4829449-B2 2011-12-07 JP claimed
JP-2003508353-A 2003-03-04 JP claimed
EP-1208097-A2 SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS Aventis Pharmaceuticals Inc. (US) 2002-05-29 EP claimed
WO-2001007436-A2 SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS AVENTIS PHARMACEUTICALS INC. (US) 2001-02-01 WO claimed