Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29954320 | 0.86 | IGF1R (0.59) | IGF1RPOLBALDH1A1KMT2ACYP1A2 | |
| SCHEMBL4205764 | 0.84 | IGF1R (0.66) | IGF1RPOLBALDH1A1KMT2ACYP1A2 | |
| SCHEMBL94996 | 0.83 | IGF1R (1.00) | IGF1RPOLBALDH1A1KMT2ACYP1A2 | |
| SCHEMBL4199341 | 0.83 | ALDH1A1 (0.65) | IGF1RPOLBALDH1A1KMT2ACYP1A2 | |
| SCHEMBL13919302 | 0.83 | IGF1R (0.76) | IGF1RPOLBALDH1A1KMT2ARAB9A | |
| SCHEMBL4208158 | 0.83 | IGF1R (0.76) | IGF1RPOLBALDH1A1KMT2A | |
| SCHEMBL4494376 | 0.82 | IGF1R (0.79) | IGF1RPOLBALDH1A1KMT2ARAB9A | |
| SCHEMBL14195910 | 0.80 | IGF1R (0.80) | IGF1RPOLBALDH1A1KMT2ACYP1A2 | |
| SCHEMBL4206559 | 0.79 | IGF1R (0.60) | IGF1RPOLBALDH1A1KMT2ARAB9A | |
| SCHEMBL4200301 | 0.78 | IGF1R (0.58) | IGF1RPOLBALDH1A1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538231-B2 | Tyrosine kinase inhibitors | MERCK & CO, INC. (US) | 2009-05-26 | — | — | US | disclosed |