Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 14/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865194 | 0.90 | BUB1 (0.45) | BUB1PDE5ACHRM1CYP1A2CYP2D6 | |
| SCHEMBL4434101 | 0.86 | BUB1 (0.45) | BUB1PDE5ACHRM1 | |
| SCHEMBL13865218 | 0.85 | BUB1 (0.48) | BUB1PDE5ACHRM1CYP1A2CYP2D6 | |
| SCHEMBL4426683 | 0.80 | BUB1 (0.43) | BUB1PDE5ACHRM1CYP1A2CYP2D6 | |
| SCHEMBL13865215 | 0.79 | BUB1 (0.53) | BUB1 | |
| SCHEMBL4425532 | 0.77 | BUB1 (0.45) | BUB1PDE5ACHRM1CYP1A2CYP2D6 | |
| SCHEMBL13865208 | 0.76 | BUB1 (0.48) | BUB1CHRM1CYP1A2CYP2D6 | |
| SCHEMBL13865183 | 0.76 | CYP2D6 (0.52) | BUB1CHRM1CYP1A2CYP2D6 | |
| SCHEMBL13865181 | 0.74 | BUB1 (0.44) | BUB1CHRM1 | |
| SCHEMBL4425835 | 0.73 | CHRM1 (0.44) | BUB1PDE5ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934311-B1 | NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES | BAYER HEALTHCARE AG (DE) | 2009-05-13 | — | — | EP | disclosed |