Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561802 | 0.83 | GAA (0.44) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL13863998 | 0.81 | TSHR (0.38) | CYP2C19CYP2D6TSHRHIF1AALDH1A1 | |
| SCHEMBL12831035 | 0.78 | GAA (0.48) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL27685123 | 0.78 | GAA (0.48) | GAAMGAMSIMGAM2CYP2C19 | |
| SCHEMBL1544762 | 0.78 | HSD11B1 (0.49) | GAAMGAMSIMGAM2CYP2C19 | |
| SCHEMBL8222484 | 0.77 | GAA (0.46) | GAAMGAMSIMGAM2CYP2C19 | |
| SCHEMBL6667305 | 0.77 | TET2 (0.47) | GAAMGAMSIMGAM2CYP2C19 | |
| SCHEMBL29196260 | 0.76 | CYP1A2 (0.47) | GAAMGAMSIMGAM2CYP2C19 | |
| SCHEMBL5973054 | 0.76 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL10447420 | 0.76 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7537765-B2 | Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein | PANACOS PHARMACEUTICALS, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-20080233559-A1 | Inhibition of HIV-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein | PANACOS PHARMACEUTICALS, INC. | 2008-09-25 | — | — | US | disclosed |