Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 16/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | GC | P02774 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681026 | 0.94 | VDR (0.54) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL8091700 | 0.92 | VDR (0.54) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL25313440 | 0.92 | VDR (0.54) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL25313435 | 0.92 | VDR (0.54) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL12408062 | 0.91 | VDR (0.51) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL5681072 | 0.91 | VDR (0.51) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL7151478 | 0.90 | VDR (0.47) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL25310518 | 0.90 | VDR (0.47) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL8527611 | 0.90 | VDR (0.47) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL5680998 | 0.90 | VDR (0.47) | VDRMAPTADORA3SLC6A2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073885-B2 | Vitamin D3 lactone derivatives | TEIJIN PHARMA LIMITED (JP) | 2015-07-07 | — | — | US | disclosed |
| US-7524980-B2 | vitamin D3 antagonist activity; treating Paget's disease, bone diseases, hypercalcemia or osteoporosis; e.g. 1 alpha,25-dihydroxyvitamin D3-26 23-lactam, N-(p-methoxy)benzyl | TEIJIN PHARMA LIMITED (JP) | 2009-04-28 | — | — | US | disclosed |