Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187826 | 1.00 | KDR (0.56) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4554641 | 1.00 | KDR (0.56) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4553064 | 0.93 | KDR (0.52) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4554186 | 0.93 | KDR (0.54) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13867895 | 0.90 | KDR (0.51) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4765293 | 0.88 | TUBB4A (0.45) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4553873 | 0.87 | KDR (0.54) | KDRTRPV1LMNAMETNPC1 | |
| SCHEMBL3903045 | 0.86 | KDR (0.55) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL198207 | 0.86 | KDR (0.55) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3902473 | 0.86 | KDR (0.56) | KDRTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |