Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3890961 | 0.90 | KDR (0.56) | KDRTRPV1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3815901 | 0.88 | KDR (0.40) | KDRNR1H2RAB9ASMN1; SMN2WEE1 | |
| SCHEMBL3959803 | 0.83 | KDR (0.39) | KDRNR1H2RAB9AWEE1FLT1 | |
| SCHEMBL187231 | 0.81 | KDR (0.59) | KDRTRPV1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3898376 | 0.80 | KDR (0.54) | KDRTRPV1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4975909 | 0.80 | VCP (0.43) | KDRNR1H2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3818526 | 0.80 | POLB (0.50) | KDRNR1H2RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL445073 | 0.80 | NR1H2 (0.41) | KDRNR1H2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL631358 | 0.80 | KDR (0.55) | KDRTRPV1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3891371 | 0.80 | KDR (0.56) | KDRTRPV1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |