Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 5/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13867982 | 0.84 | CHRNB4 (0.61) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL15037237 | 0.84 | CHRNB4 (0.61) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL16729424 | 0.75 | F2 (0.43) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL2603269 | 0.72 | CHRM3 (0.51) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL15032896 | 0.72 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL25594625 | 0.72 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL450027 | 0.71 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL447049 | 0.71 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL447762 | 0.71 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL15945458 | 0.70 | RBP4 (0.43) | RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514564-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2009-04-07 | — | — | US | disclosed |
| EP-1562933-B1 | SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS | AMGEN INC (US) | 2008-03-19 | — | — | EP | disclosed |