Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904433 | 1.00 | KMT2A (0.41) | KMT2AMEN1HTTATMKDM4E | |
| SCHEMBL13868383 | 0.88 | BRD4 (0.45) | KMT2AMEN1ATMGAA | |
| SCHEMBL3914695 | 0.83 | HTT (0.44) | KMT2AMEN1HTTATMKDM4E | |
| SCHEMBL3904597 | 0.82 | MEN1 (0.42) | KMT2AMEN1 | |
| SCHEMBL13868448 | 0.82 | MEN1 (0.42) | KMT2AMEN1 | |
| SCHEMBL13878948 | 0.82 | HTT (0.42) | KMT2AMEN1HTTATMKDM4E | |
| SCHEMBL3902825 | 0.78 | ALDH1A1 (0.44) | KMT2AMEN1TP53HCRTR2GAA | |
| SCHEMBL13868382 | 0.78 | BRD4 (0.45) | ATMKDM4EGAA | |
| SCHEMBL3912851 | 0.73 | HTT (0.44) | KMT2AMEN1HTTATMKDM4E | |
| SCHEMBL3914346 | 0.72 | HTT (0.54) | HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517532-B2 | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-7517532-B2 | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-04-14 | — | — | US | disclosed |