Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 10/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978991 | 0.84 | GFER (0.57) | LMNAGAAMEN1KMT2ARAB9A | |
| SCHEMBL3974243 | 0.84 | DHODH (0.50) | LMNAGAAMEN1KMT2ARAB9A | |
| SCHEMBL6341341 | 0.82 | MEN1 (0.54) | LMNAGAAMEN1KMT2ARAB9A | |
| SCHEMBL13869101 | 0.80 | MAPT (0.44) | LMNAGAAMEN1KMT2ARAB9A | |
| SCHEMBL5253749 | 0.80 | GFER (0.61) | LMNAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5310758 | 0.77 | SMN1; SMN2 (0.46) | LMNAGAAMEN1KMT2AMAPT | |
| SCHEMBL3973229 | 0.74 | NTRK1 (0.54) | LMNAGAAKMT2ARAB9ANPC1 | |
| SCHEMBL5469997 | 0.73 | SMN1; SMN2 (0.47) | MEN1KMT2AMAPTDHODHHTT | |
| SCHEMBL11707284 | 0.73 | CLCN2 (0.47) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5005305 | 0.73 | TAS2R14 (0.46) | MEN1KMT2AMAPTDHODHHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517878-B2 | Heteroarylaminopyrazole derivatives useful for the treatment of diabetes | BAYER PHARAMCEUTICALS CORPORATION (US) | 2009-04-14 | — | — | US | disclosed |
| US-7517878-B2 | Heteroarylaminopyrazole derivatives useful for the treatment of diabetes | BAYER PHARAMCEUTICALS CORPORATION (US) | 2009-04-14 | — | — | US | disclosed |