Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 10/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 10/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825250 | 0.98 | POLB (0.53) | POLBMAPTTDP1NPSR1KMT2A | |
| SCHEMBL28726197 | 0.93 | — | — | |
| SCHEMBL21402172 | 0.88 | — | — | |
| Cyanide SCHEMBL27344551 | 0.82 | POLB (0.52) | POLBMAPTTDP1NPSR1KMT2A | |
| SCHEMBL8726534 | 0.80 | TDP1 (0.50) | POLBMAPTTDP1NPSR1KMT2A | |
| SCHEMBL20908426 | 0.78 | MAPT (0.48) | POLBMAPTTDP1NPSR1KMT2A | |
| SCHEMBL8372303 | 0.78 | CHRM5 (0.52) | POLBMAPTTDP1NPSR1KMT2A | |
| SCHEMBL18608234 | 0.78 | TDP1 (0.48) | POLBMAPTTDP1NPSR1KMT2A | |
| SCHEMBL3258927 | 0.78 | POLB (0.48) | POLBMAPTTDP1NPSR1KMT2A | |
| SCHEMBL3438539 | 0.77 | MAPT (0.61) | POLBMAPTTDP1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4787150-B2 | — | — | 2011-10-05 | — | — | JP | claimed |
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI CO., LTD. (JP) | 2011-07-07 | — | — | US | claimed |
| EP-2295433-A2 | JNK inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2011-03-16 | — | — | EP | claimed |
| EP-1720871-B1 | 3,5-DISUBSTITUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2010-05-19 | — | — | EP | claimed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | claimed |
| US-20060270646-A1 | Jnk inhibitors | EISAI CO., LTD. (JP) | 2006-11-30 | — | — | US | claimed |
| EP-1720871-A1 | 3,5-DISUBSTITUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | Eisai London Research Laboratories Limited (GB) | 2006-11-15 | — | — | EP | claimed |
| EP-1599475-A2 | JNK INHIBITORS | Eisai Co., Ltd. (JP) | 2005-11-30 | — | — | EP | claimed |
| WO-2005085244-A1 | 3,5-DISUBSTITUTED 1H-PZRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI LONDON RESEARCH LABORATORIES LIMITED (GB) | 2005-09-15 | — | — | WO | claimed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | claimed |
| EP-0783486-B1 | NOVEL PROSTAGLANDIN SYNTHASE INHIBITORS | DU PONT PHARM CO (US) | 1999-10-13 | — | — | EP | claimed |
| US-5763627-A | Process for preparing cyclopropyl alkyl ketones and 4,5-dihydroalkyfurans | HUELS AKTIENGESELLSCHAFT (DE) | 1998-06-09 | — | — | US | claimed |
| CN-106661386-A | Laminate optical film production method | 日东电工株式会社 | 2017-05-10 | — | — | CN | disclosed |
| EP-2875017-A1 | DERIVATIVES OF 1-(SUBSTITUTED SULFONYL)-2-AMINOIMIDAZOLINE AS ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | ONCOARENDI THERAPEUTICS SP. Z.O.O. (PL) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014167446-A1 | DERIVATIVES OF 1-(SUBSTITUTED SULFONYL)-2-AMINOIMIDAZOLINE AS ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2014-10-16 | — | — | WO | disclosed |
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| EP-0725066-A1 | Process for the production of cyclopropylalkylketones and 4,5-dihydroalkylfuranes | HÜLS AKTIENGESELLSCHAFT (DE) | 1996-08-07 | — | — | EP | disclosed |
| EP-0511036-A1 | Synthesis intermediaries with an hexanic ring, and process for their preparation | RHONE-POULENC CHIMIE (FR) | 1992-10-28 | — | — | EP | disclosed |
| EP-0248393-B1 | METHOD FOR THE PREPARATION OF ACYLATED HETEROAROMATICS AT ZEOLITHIC CATALYSTS | BASF Aktiengesellschaft (DE) | 1991-08-07 | — | — | EP | disclosed |
| EP-0248393-A1 | Method for the preparation of acylated heteroaromatics at zeolithic catalysts | BASF Aktiengesellschaft (DE) | 1987-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | API5, CDK5, MAPKAPK5 | POLB 3701/4885MAPT 249/4885TDP1 333/4885 |
| US-20060270646-A1 | Jnk inhibitors | MAPKAPK2, MAPK1, MAPKAPK3 | POLB 2411/4885MAPT 87/4885TDP1 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.