Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 17/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533614 | 0.87 | PTGDR2 (0.71) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL5476456 | 0.85 | PTGDR2 (0.72) | PTGDR2AKR1B1 | |
| SCHEMBL1384482 | 0.85 | PTGDR2 (0.75) | PTGDR2AKR1B1CYP2C9ALDH1A1MAPK1 | |
| SCHEMBL5477529 | 0.78 | PTGDR2 (0.62) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL5438307 | 0.76 | PTGDR2 (0.60) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL1406046 | 0.76 | PTGDR2 (0.78) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL5428186 | 0.75 | PTGDR2 (0.61) | PTGDR2CYP2C9 | |
| SCHEMBL5474079 | 0.74 | PTGDR2 (0.63) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL3010082 | 0.74 | PTGDR2 (0.46) | PTGDR2AKR1B1CYP2C9ALDH1A1MAPK1 | |
| SCHEMBL5474051 | 0.74 | PTGDR2 (0.56) | PTGDR2AKR1B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4791729-B2 | — | — | 2011-10-12 | — | — | JP | claimed |
| JP-2005537265-A | — | — | 2005-12-08 | — | — | JP | claimed |
| EP-1551802-A1 | INDOLE-3-SULPHUR DERIVATIVES | AstraZeneca AB (SE) | 2005-07-13 | — | — | EP | claimed |
| WO-2004007451-A1 | INDOLE-3-SULPHUR DERIVATIVES | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | claimed |