Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | USP2 | O75604 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | CDKN1A | P38936 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923125 | 0.90 | HSD11B1 (0.47) | MAPTUSP2NPSR1KDM4EALDH1A1 | |
| SCHEMBL2925815 | 0.86 | HSD11B1 (0.48) | MAPTUSP2NPSR1KDM4EALDH1A1 | |
| SCHEMBL2917261 | 0.84 | MAPT (0.43) | MAPTUSP2NPSR1KDM4EALDH1A1 | |
| SCHEMBL13869812 | 0.83 | RXFP1 (0.47) | MAPTUSP2NPSR1KDM4EALDH1A1 | |
| SCHEMBL2925396 | 0.82 | MEN1 (0.42) | MAPTKDM4EALDH1A1POLBHPGD | |
| SCHEMBL2922001 | 0.81 | MAPT (0.41) | MAPTUSP2NPSR1KDM4EALDH1A1 | |
| SCHEMBL2918293 | 0.79 | MAPT (0.43) | MAPTUSP2NPSR1KDM4EALDH1A1 | |
| SCHEMBL2925659 | 0.77 | HSD11B1 (0.62) | MAPTKDM4EALDH1A1POLBHPGD | |
| SCHEMBL2917535 | 0.76 | HSD11B1 (0.61) | MAPTUSP2NPSR1KDM4EALDH1A1 | |
| SCHEMBL2924591 | 0.75 | HSD11B1 (0.46) | MAPTKDM4EALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7465739-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-16 | — | — | US | disclosed |
| US-7465739-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-16 | — | — | US | disclosed |