Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SGK1 | O00141 | 2/20 | 0.36 |
| ▸ | LATS1 | O95835 | 5/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 5/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13870001 | 0.87 | PDE5A (0.41) | POLBLMNAHPGDMAPTABCG2 | |
| SCHEMBL4016508 | 0.84 | POLB (0.39) | POLBSGK1LATS1LATS2ROCK2 | |
| SCHEMBL13869998 | 0.84 | MAT2A (0.31) | SGK1 | |
| SCHEMBL13870003 | 0.82 | NPC1 (0.43) | LMNAMAPTALDH1A1 | |
| SCHEMBL13869995 | 0.82 | NPC1 (0.34) | — | |
| SCHEMBL13870040 | 0.82 | SGK1 (0.32) | SGK1ABCG2 | |
| SCHEMBL13870013 | 0.82 | ABCG2 (0.37) | LMNAHPGDMAPTABCG2ALDH1A1 | |
| SCHEMBL13870046 | 0.80 | PRKD1 (0.34) | SGK1LMNA | |
| SCHEMBL13870015 | 0.80 | MAPT (0.36) | POLBHPGDMAPTHDAC6ALDH1A1 | |
| SCHEMBL13870009 | 0.79 | HDAC6 (0.37) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524849-B2 | Antitumor agents to treat multiple drug resistant tumors; promoters of microtubule polymerization; etherification | WYETH HOLDINGS CORPORATION (US) | 2009-04-28 | — | — | US | disclosed |