Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13870489 | 0.84 | NPC1 (0.48) | PI4KAPI4KBALDH1A1MAPK14CNR1 | |
| SCHEMBL14374418 | 0.84 | MAPT (0.41) | MAPTMAPK10MAPK8PI4KAPI4KB | |
| SCHEMBL4079304 | 0.84 | PI4KA (0.39) | MAPTPI4KAPI4KBLMNAMAPK1 | |
| SCHEMBL4075117 | 0.83 | MEN1 (0.43) | PI4KAPI4KBMAPK1GHSRMEN1 | |
| SCHEMBL13870441 | 0.82 | HPGD (0.45) | MAPTPI4KAPI4KBMEN1KMT2A | |
| SCHEMBL4088399 | 0.80 | LMNA (0.41) | MAPTPI4KAPI4KBLMNAALDH1A1 | |
| SCHEMBL4078693 | 0.79 | MAPK14 (0.38) | MAPTPI4KAPI4KBMAPK1ALDH1A1 | |
| SCHEMBL13870458 | 0.79 | MAPK14 (0.36) | MAPTPI4KAPI4KBLMNAMAPK1 | |
| SCHEMBL4078477 | 0.77 | GCK (0.35) | MAPTPI4KAPI4KBLMNAMAPK1 | |
| SCHEMBL2143887 | 0.77 | GCK (0.38) | MAPTLMNAMAPK1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517995-B2 | Thiazolyl-dihydro-cyclopentapyrazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-14 | — | — | US | disclosed |
| US-7517995-B2 | Thiazolyl-dihydro-cyclopentapyrazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-14 | — | — | US | disclosed |
| WO-2007115931-A1 | THIAZOLYLDIHYDROCYCLOPENTAPYRAZOLES FOR USE AS PI3-KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |