Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 7/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13870558 | 0.92 | KCNH2 (0.46) | KCNH2HRH1TBXA2RADRA1DADRA1A | |
| SCHEMBL13870537 | 0.89 | KCNH2 (0.45) | KCNH2HRH1ADRA1DADRA1AADRA1B | |
| SCHEMBL9718791 | 0.87 | KCNH2 (0.56) | KCNH2HRH1AKR1B1LMNAALDH1A1 | |
| SCHEMBL14307767 | 0.84 | ALDH1A1 (0.51) | KCNH2HRH1TBXA2RLMNAALDH1A1 | |
| SCHEMBL13870534 | 0.83 | KCNH2 (0.68) | KCNH2HRH1TBXA2RLMNA | |
| Hydrochloric Acid SCHEMBL3139244 | 0.83 | KCNH2 (0.46) | KCNH2HRH1LMNA | |
| SCHEMBL3131124 | 0.81 | HRH1 (0.57) | KCNH2HRH1TBXA2RADRA1DADRA1A | |
| SCHEMBL13870556 | 0.81 | KCNH2 (0.43) | KCNH2HRH1ADRA1DADRA1AADRA1B | |
| SCHEMBL9718719 | 0.81 | KCNH2 (0.54) | KCNH2HRH1MAPT | |
| Hydrochloric Acid SCHEMBL9718768 | 0.80 | KCNH2 (0.53) | KCNH2HRH1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524864-B2 | Methods of treating sleep disorders | HYPNION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7482460-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7411069-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7326721-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |