Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 11/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 11/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | LITAF | Q99732 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | USP19 | O94966 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651084 | 0.88 | DDB1 (0.58) | DDB1CRBNIKZF3TNFALDH1A1 | |
| SCHEMBL23979481 | 0.84 | DDB1 (0.50) | DDB1CRBNIKZF3PARP1NPC1 | |
| SCHEMBL13871000 | 0.77 | DDB1 (0.46) | DDB1CRBNIKZF3PARP1TRPA1 | |
| SCHEMBL13833757 | 0.76 | KDM4E (0.47) | PARP1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL19586333 | 0.74 | CRBN (0.74) | DDB1CRBNIKZF3TNFALDH1A1 | |
| SCHEMBL26043071 | 0.74 | DDB1 (0.57) | DDB1CRBNIKZF3TNFALDH1A1 | |
| SCHEMBL24132073 | 0.74 | DDB1 (0.57) | DDB1CRBNIKZF3TNFALDH1A1 | |
| SCHEMBL23066001 | 0.74 | DDB1 (0.74) | DDB1CRBNIKZF3TNFALDH1A1 | |
| SCHEMBL16768177 | 0.73 | DDB1 (0.49) | DDB1CRBNIKZF3PARP1TNF | |
| SCHEMBL26138528 | 0.70 | DDB1 (0.34) | DDB1CRBNIKZF3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492395-B2 | 7-substituted quinazolinone compounds and compositions comprising the same | CELGENE CORPORATION (US) | 2013-07-23 | — | — | US | disclosed |
| US-20090093504-A1 | 6-, 7-, or 8-Substituted Quinazolinone Derivatives and Compositions Comprising and Methods of Using the Same | CELGENE CORPORATION | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093504-A1 | 6-, 7-, or 8-Substituted Quinazolinone Derivatives and Compositions Comprising and Methods of Using the Same | CYP3A7, CYP2D6, CYP2B6 | DDB1 3263/4885CRBN 3949/4885IKZF3 4761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.