SCHEMBL1387183

SCHEMBL1387183

c1ccc(COc2cccc(Nc3ncnc4ccccc34)c2)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 12/20 0.75
ERBB2 P04626 5/20 0.75
AURKB Q96GD4 3/20 0.75
CLK4 Q9HAZ1 3/20 0.75
CHEK2 O96017 1/20 0.75
ROS1 P08922 1/20 0.75
FLT3 P36888 1/20 0.75
ERBB4 Q15303 1/20 0.75
MKNK2 Q9HBH9 1/20 0.75
ABCG2 Q9UNQ0 4/20 0.69
MAP4K4 O95819 2/20 0.69
LTK P29376 2/20 0.69
MAPK8 P45983 2/20 0.69
LIMK1 P53667 2/20 0.69
ACVR1 Q04771 2/20 0.69
DYRK1A Q13627 2/20 0.69
MAPK14 Q16539 2/20 0.69
LRRK2 Q5S007 2/20 0.69
DYRK1B Q9Y463 2/20 0.69
KDR P35968 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8807683 0.99 EGFR (0.73) EGFRERBB2AURKBCLK4CHEK2
SCHEMBL15607573 0.87 EGFR (0.78) EGFRERBB2AURKBCLK4CHEK2
SCHEMBL6664796 0.87 HTT (0.67) EGFRERBB2AURKBCLK4CHEK2
SCHEMBL1387226 0.86 EGFR (1.00) EGFRERBB2AURKBCLK4CHEK2
SCHEMBL8807926 0.86 EGFR (0.90) EGFRERBB2AURKBCLK4CHEK2
Hydrochloric Acid SCHEMBL8810027 0.85 EGFR (0.97) EGFRERBB2AURKBCLK4CHEK2
SCHEMBL14262811 0.82 ABCG2 (0.71) ABCG2SMN1; SMN2MEN1MAPTKMT2A
SCHEMBL9017043 0.82 EGFR (1.00) EGFRAURKBCLK4ABCG2MAP4K4
SCHEMBL19917118 0.80 MAOB (0.54) EGFRERBB2AURKBCLK4CHEK2
SCHEMBL15923162 0.80 PTK6 (0.67) EGFRERBB2AURKBCLK4CHEK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-H10505600-A 1998-06-02 JP claimed
EP-0782570-A1 SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE THE WELLCOME FOUNDATION LIMITED (GB) 1997-07-09 EP claimed
WO-1996009294-A1 SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE THE WELLCOME FOUNDATION LIMITED (GB) 1996-03-28 WO claimed
EP-0782570-A1 SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE THE WELLCOME FOUNDATION LIMITED (GB) 1997-07-09 EP disclosed
WO-1996009294-A1 SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE THE WELLCOME FOUNDATION LIMITED (GB) 1996-03-28 WO disclosed