Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 10/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | ROS1 | P08922 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | GRK5 | P34947 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6663913 | 0.89 | EGFR (0.79) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL1387183 | 0.87 | EGFR (0.75) | HTTKDM4EEGFRERBB2AURKB | |
| Hydrochloric Acid SCHEMBL8807683 | 0.86 | EGFR (0.73) | HTTEGFRERBB2AURKBCLK4 | |
| SCHEMBL14595168 | 0.83 | EGFR (0.74) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL2101381 | 0.82 | HTT (1.00) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL5569459 | 0.81 | HTT (0.69) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL8871863 | 0.80 | EGFR (0.82) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL5569022 | 0.78 | HTT (0.72) | HTTMAPK1KDM4EEGFRERBB2 | |
| SCHEMBL8870651 | 0.78 | EGFR (0.81) | MAPK1KDM4EEGFRERBB2ERBB4 | |
| SCHEMBL16545883 | 0.78 | EGFR (0.64) | HTTEGFRERBB2ERBB4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |