Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | THRB | P10828 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13872274 | 0.92 | MEN1 (0.32) | MEN1KMT2AALOX15HPGDCYP1A2 | |
| SCHEMBL13871905 | 0.88 | MEN1 (0.39) | MEN1KMT2AALOX15HPGDCYP1A2 | |
| SCHEMBL13113656 | 0.87 | ALOX15 (0.43) | MEN1KMT2AALOX15HPGDCYP1A2 | |
| SCHEMBL13871950 | 0.86 | MEN1 (0.38) | MEN1KMT2AALOX15HPGDCYP1A2 | |
| SCHEMBL13871966 | 0.84 | MEN1 (0.40) | MEN1KMT2AALOX15HPGDCYP1A2 | |
| SCHEMBL13871911 | 0.84 | PRKCI (0.35) | — | |
| SCHEMBL13872273 | 0.83 | METAP1 (0.35) | MEN1KMT2AALOX15HPGDCYP1A2 | |
| SCHEMBL13871983 | 0.82 | MEN1 (0.40) | MEN1KMT2AALOX15HPGDCYP1A2 | |
| SCHEMBL13871869 | 0.81 | HTR2C (0.34) | MEN1KMT2AALOX15HPGDCYP1A2 | |
| SCHEMBL13871937 | 0.79 | MEN1 (0.36) | MEN1KMT2AALOX15HSD17B10PABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |