SCHEMBL1387230

SCHEMBL1387230

COc1cc2nccc(Nc3ccc(N4C(=O)c5ccc(Cl)cc5C4=O)c(C)c3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERBB2 P04626 1/20 1.00
EGFR P00533 5/20 0.54
SRC P12931 3/20 0.53
KDR P35968 6/20 0.49
GAK O14976 5/20 0.48
RIPK2 O43353 2/20 0.48
COQ8A Q8NI60 2/20 0.48
NLK Q9UBE8 2/20 0.48
BMPR1B O00238 1/20 0.48
EPHB6 O15197 1/20 0.48
ABL1 P00519 1/20 0.48
LCK P06239 1/20 0.48
EPHA1 P21709 1/20 0.48
EPHA8 P29322 1/20 0.48
ACVR1 Q04771 1/20 0.48
MAP2K5 Q13163 1/20 0.48
FLT1 P17948 2/20 0.48
FGFR1 P11362 1/20 0.48
PDGFRA P16234 4/20 0.47
TGFBR1 P36897 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8934058 0.99 ERBB2 (0.98) ERBB2EGFRSRCKDRGAK
Hydrochloric Acid SCHEMBL8934071 0.84 ERBB2 (0.72) ERBB2EGFRKDRTGFBR1GRM1
Hydrochloric Acid SCHEMBL8934001 0.81 ERBB2 (0.68) ERBB2EGFRKDRGRM1GRM4
SCHEMBL12484448 0.74 EGFR (0.73) ERBB2EGFRSRCKDRGAK
Hydrochloric Acid SCHEMBL7659452 0.73 ERBB2 (0.57) ERBB2GRM1GRM4
SCHEMBL27751680 0.72 EGFR (0.70) ERBB2EGFRSRCKDRGAK
SCHEMBL21121575 0.72 GAK (0.77) ERBB2EGFRSRCGAKRIPK2
SCHEMBL31067663 0.72 PDGFRA (0.81) EGFRSRCKDRGAKRIPK2
SCHEMBL6434027 0.71 EGFR (0.72) ERBB2EGFRSRCKDRGAK
SCHEMBL5903417 0.71 ESR1 (0.61) ERBB2GRM1GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-H10505600-A 1998-06-02 JP claimed
WO-1996009294-A1 SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE THE WELLCOME FOUNDATION LIMITED (GB) 1996-03-28 WO claimed
EP-0782570-A1 SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE THE WELLCOME FOUNDATION LIMITED (GB) 1997-07-09 EP disclosed
WO-1996009294-A1 SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE THE WELLCOME FOUNDATION LIMITED (GB) 1996-03-28 WO disclosed