Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | INSR | P06213 | 1/20 | 0.67 |
| ▸ | FBP1 | P09467 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | FLT4 | P35916 | 1/20 | 0.67 |
| ▸ | CLK1 | P49759 | 1/20 | 0.67 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.67 |
| ▸ | TEK | Q02763 | 1/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 3/20 | 0.65 |
| ▸ | GAK | O14976 | 3/20 | 0.62 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27751699 | 0.92 | KDR (0.73) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL28778139 | 0.91 | EGFR (0.60) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL31213837 | 0.89 | EGFR (0.61) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL6352042 | 0.83 | EGFR (0.75) | EGFRERBB2KDRSRCGAK | |
| SCHEMBL28447436 | 0.83 | EGFR (0.66) | EGFRERBB2KDRPDGFRBSRC | |
| SCHEMBL12308286 | 0.83 | EGFR (0.77) | EGFRERBB2KDRFLT4EPHB4 | |
| SCHEMBL12484448 | 0.82 | EGFR (0.73) | EGFRERBB2KDRFBP1PDGFRB | |
| SCHEMBL28445612 | 0.81 | EGFR (0.68) | EGFRERBB2KDRPDGFRBSRC | |
| SCHEMBL30505605 | 0.81 | EGFR (1.00) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL2099106 | 0.81 | EGFR (1.00) | EGFRERBB2KDRAURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101362719-B | Chinolines derivates and composition containing thereof | UNIV BEIJING NORMAL | 2012-04-18 | — | — | CN | disclosed |
| CN-101362719-A | Chinolines derivates and composition containing thereof | UNIV BEIJING NORMAL (CN) | 2009-02-11 | — | — | CN | disclosed |