Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | CCR4 | P51679 | 1/20 | 0.55 |
| ▸ | EDNRB | P24530 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL795555 | 0.90 | EDNRA (0.66) | EDNRAABCB11CCR4 | |
| SCHEMBL1387409 | 0.89 | EDNRA (1.00) | EDNRAABCB11CCR4 | |
| SCHEMBL1387204 | 0.89 | EDNRA (0.79) | EDNRAABCB11CCR4 | |
| SCHEMBL7424965 | 0.89 | ABCB11 (0.71) | EDNRAABCB11CCR4 | |
| SCHEMBL7366024 | 0.87 | ABCB11 (1.00) | EDNRAABCB11CCR4 | |
| SCHEMBL1387397 | 0.87 | EDNRA (0.67) | EDNRAABCB11CCR4 | |
| SCHEMBL1387150 | 0.86 | EDNRA (0.77) | EDNRAABCB11CCR4 | |
| SCHEMBL1387249 | 0.86 | EDNRA (0.66) | EDNRAABCB11CCR4 | |
| SCHEMBL1387274 | 0.85 | EDNRA (0.60) | EDNRAABCB11CCR4 | |
| SCHEMBL1387336 | 0.85 | CCR4 (0.66) | EDNRAABCB11CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752986-B1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LTD (GB) | 1999-05-19 | — | — | EP | claimed |
| US-5861401-A | TREATMENT OF CONGESTIVE HEART FAILURE | ZENECA LIMITED (GB) | 1999-01-19 | — | — | US | claimed |
| JP-H09510987-A | — | — | 1997-11-04 | — | — | JP | claimed |
| EP-0752986-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1997-01-15 | — | — | EP | claimed |
| WO-1995026957-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1995-10-12 | — | — | WO | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-6083951-A | FOR THE TREATMENT OF DISEASES OR MEDICAL CONDITIONS SUCH AS HYPERTENSION, PULMONARY HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE | ZENECA LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| US-5861401-A | TREATMENT OF CONGESTIVE HEART FAILURE | ZENECA LIMITED (GB) | 1999-01-19 | — | — | US | disclosed |
| EP-0752986-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026957-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1995-10-12 | — | — | WO | disclosed |