Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | EIF4E | P06730 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | TOP1 | P11387 | 1/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | PNP | P00491 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.38 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13713970 | 1.00 | LMNA (0.60) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL13714018 | 1.00 | LMNA (0.60) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL6839414 | 1.00 | LMNA (0.60) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL14303188 | 0.80 | LMNA (0.62) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL24024691 | 0.76 | LMNA (0.63) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL7377274 | 0.76 | LMNA (0.63) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL3762066 | 0.76 | LMNA (0.63) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL6839692 | 0.76 | LMNA (0.63) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL12879149 | 0.76 | LMNA (0.63) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 | |
| SCHEMBL12892430 | 0.76 | LMNA (0.63) | LMNASMN1; SMN2ALDH1A1TSHRADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357506-B2 | Method of identifying improved conjugates of biologically active compounds | BURNET MICHAEL (DE) | 2013-01-22 | — | — | US | disclosed |
| US-8357506-B2 | Method of identifying improved conjugates of biologically active compounds | BURNET MICHAEL (DE) | 2013-01-22 | — | — | US | disclosed |
| US-20090093014-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | Burnet, Dr. Michael (DE) | 2009-04-09 | — | — | US | disclosed |
| US-20090093014-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | Burnet, Dr. Michael (DE) | 2009-04-09 | — | — | US | disclosed |