Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023425 | 0.83 | MAPT (0.68) | KDM4EALDH1A1HPGDCASP1CASP7 | |
| Hydrochloric Acid SCHEMBL3814476 | 0.83 | MAPT (0.67) | KDM4EALDH1A1HPGDCASP1CASP7 | |
| SCHEMBL13809932 | 0.77 | PLK1 (0.70) | CYP2C9MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL13872996 | 0.76 | PLK1 (0.51) | KDM4EALDH1A1HPGDCYP2C9MEN1 | |
| SCHEMBL13873249 | 0.76 | PLK1 (0.56) | MEN1KMT2APTK2BPTK2PLK1 | |
| SCHEMBL13873254 | 0.72 | PTK2 (0.68) | PTK2BPTK2AURKAPLK1SYK | |
| SCHEMBL4031609 | 0.70 | MAPT (0.70) | CYP2C9MEN1KMT2ACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL3814985 | 0.69 | MAPT (0.69) | CYP2C9MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL13088436 | 0.69 | KDM4E (0.69) | KDM4EALDH1A1HPGDCASP1CASP7 | |
| SCHEMBL30487008 | 0.69 | KDM4E (0.69) | KDM4EALDH1A1HPGDCASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |