Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 12/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | ULK1 | O75385 | 2/20 | 0.53 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13809932 | 0.89 | PLK1 (0.70) | PLK1PTK2HDAC3HDAC1HDAC2 | |
| SCHEMBL13872996 | 0.82 | PLK1 (0.51) | PLK1MAPK8MAPK9MAPK10PTK2B | |
| SCHEMBL13866466 | 0.82 | PLK1 (0.81) | PLK1PTK2HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL3814491 | 0.82 | PLK1 (0.80) | PLK1PTK2HDAC3HDAC1HDAC2 | |
| SCHEMBL28612718 | 0.77 | PTK2 (0.81) | PTK2MEN1KMT2A | |
| SCHEMBL4025643 | 0.76 | MAPK8 (0.68) | PLK1MAPK8MAPK9MAPK10IGF1R | |
| SCHEMBL13873266 | 0.76 | KDM4E (0.49) | PLK1PTK2HDAC1PTK2BMEN1 | |
| SCHEMBL22144557 | 0.76 | ULK1 (0.81) | PTK2HDAC3HDAC1HDAC2HDAC6 | |
| Hydrochloric Acid SCHEMBL3812109 | 0.75 | MAPK8 (0.67) | PLK1MAPK8MAPK9MAPK10IGF1R | |
| SCHEMBL18357332 | 0.74 | PTK2 (0.61) | PTK2ULK1PKMYT1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |