Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12568611 | 1.00 | HRH3 (0.39) | HRH3L3MBTL3L3MBTL1DPP4KCNH2 | |
| SCHEMBL9927936 | 1.00 | HRH3 (0.39) | HRH3L3MBTL3L3MBTL1DPP4KCNH2 | |
| SCHEMBL13874912 | 0.98 | DPP4 (0.40) | HRH3L3MBTL3L3MBTL1DPP4KCNH2 | |
| SCHEMBL9927929 | 0.98 | DPP4 (0.40) | HRH3L3MBTL3L3MBTL1DPP4KCNH2 | |
| SCHEMBL12568612 | 0.98 | DPP4 (0.40) | HRH3L3MBTL3L3MBTL1DPP4KCNH2 | |
| SCHEMBL9927928 | 0.89 | KDM2B (0.38) | HRH3L3MBTL3L3MBTL1DPP4KCNH2 | |
| SCHEMBL12568609 | 0.89 | KDM2B (0.38) | HRH3L3MBTL3L3MBTL1DPP4KCNH2 | |
| SCHEMBL9927914 | 0.88 | KDM2B (0.37) | L3MBTL3L3MBTL1DPP4 | |
| SCHEMBL12568610 | 0.88 | KDM2B (0.37) | L3MBTL3L3MBTL1DPP4 | |
| SCHEMBL13874479 | 0.86 | L3MBTL3 (0.47) | L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | GRAUERT MATTHIAS | 2009-04-09 | — | — | US | disclosed |
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | HRH3 387/4885L3MBTL3 2840/4885L3MBTL1 3059/4885 |
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | HRH3 387/4885L3MBTL3 2840/4885L3MBTL1 3059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.