Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27694563 | 0.93 | ADRA1B (0.46) | ADRA1BTMEM97SIGMAR1ALOX5HRH4 | |
| SCHEMBL3439991 | 0.91 | ADRA1B (0.48) | ADRA1BTMEM97SIGMAR1ALOX5HRH4 | |
| SCHEMBL13874794 | 0.91 | TMEM97 (0.34) | ADRA1BTMEM97 | |
| SCHEMBL21088841 | 0.88 | ADRA1B (0.41) | ADRA1BTMEM97SIGMAR1ALOX5HRH4 | |
| SCHEMBL13711851 | 0.88 | ADRA1B (0.46) | ADRA1BTMEM97SIGMAR1ALOX5HRH4 | |
| SCHEMBL13711904 | 0.86 | ADRA1B (0.48) | ADRA1BTMEM97SIGMAR1ALOX5HRH4 | |
| SCHEMBL19720283 | 0.86 | ADRA1B (0.48) | ADRA1BTMEM97SIGMAR1ALOX5HRH4 | |
| SCHEMBL5199733 | 0.83 | ADRA1B (0.41) | ADRA1BTMEM97SIGMAR1ALOX5HRH4 | |
| SCHEMBL9941985 | 0.83 | — | — | |
| SCHEMBL13280102 | 0.81 | ADRA1B (0.44) | ADRA1BTMEM97SIGMAR1ALOX5HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | GRAUERT MATTHIAS | 2009-04-09 | — | — | US | disclosed |
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | ADRA1B 288/4885TMEM97 1998/4885SIGMAR1 1315/4885 |
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | ADRA1B 288/4885TMEM97 1998/4885SIGMAR1 1315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.