ADRA1B

Alpha-1B adrenergic receptor · P35368 · ADRA1B on Sugi Atlas →

186,031 patent compounds predicted against ADRA1B, 120,507 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Silodosin (SCHEMBL136973)	1.00	20/20
Azelastine (SCHEMBL4239)	1.00	17/20
Azelastine (SCHEMBL4240)	1.00	17/20
Azelastine (SCHEMBL36770)	1.00	17/20
Azelastine (SCHEMBL36771)	1.00	17/20
Medroxalol (SCHEMBL120537)	0.98	14/20
Labetalol (SCHEMBL41230)	1.00	13/20
Flezelastine (SCHEMBL62291)	0.66	13/20
Labetalol (SCHEMBL4582)	1.00	12/20
Brimonidine (SCHEMBL24670)	1.00	12/20
Labetalol (SCHEMBL41231)	1.00	12/20
Dilevalol (SCHEMBL79468)	1.00	12/20
Brimonidine (SCHEMBL34648)	0.84	12/20
Brimonidine (SCHEMBL34647)	1.00	11/20
Brimonidine (SCHEMBL34649)	1.00	11/20
Protokylol (SCHEMBL50567)	0.76	11/20
Tamsulosin (SCHEMBL34378)	1.00	9/20
Tamsulosin (SCHEMBL53998)	1.00	9/20
Tamsulosin (SCHEMBL23428)	0.98	9/20
Tamsulosin (SCHEMBL23429)	0.96	9/20

Clinical trials — most relevant to ADRA1B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences	PHASE4	RECRUITING
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.	PHASE4	COMPLETED
Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma	PHASE3	COMPLETED
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure	PHASE3	COMPLETED
Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome	PHASE3	RECRUITING
MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients	PHASE2/PHASE3	UNKNOWN
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder	PHASE2	COMPLETED
Mechanisms for Activation of Beige Adipose Tissue in Humans	PHASE2	RECRUITING
Dose Response and Receptor Selectivity of Beta-blocker Effects on Bone Metabolism	EARLY_PHASE1	COMPLETED
Comparative Study Between the Efficacy of Verapamil and Bisoprolol on Reduction of Bleeding During Endoscopic Sinus Surgery Under General Anaesthesia.	EARLY_PHASE1	UNKNOWN
Propranolol for the Treatment of Traumatic Brain Injury	EARLY_PHASE1	UNKNOWN
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
Can Caudal Dexmedetomidine Provide Effective Analgesia?	nan	NOT_YET_RECRUITING
Beta-Blockers on Neoadjuvant Immunochemotherapy for Hypertensive Patients With Gastric Cancer	nan	ACTIVE_NOT_RECRUITING
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Influence of Nebivolol on Postmenopausal Women	nan	UNKNOWN
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Renal Denervation in Patients With Chronic Heart Failure	nan	WITHDRAWN
Genetic Determinants of Response to Beta Blockade	nan	COMPLETED
Effect of Time-restricted Eating on Catecholamine-sensitivity of Adipose Tissue in Obese Adults	nan	ACTIVE_NOT_RECRUITING
The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension	nan	COMPLETED
The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart Failure	nan	COMPLETED
Clinical Effect and Safety of Tamsulosin 0.4mg in Patients With LUTS/BPH Refractory to Tamsulosin 0.2mg	nan	UNKNOWN
Comparative Study Between Behavior Therapy and Behavior Therapy Plus Mirabegron in Sexually Active Men With OAB Symptoms	nan	COMPLETED
Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia	nan	COMPLETED
Activation of Brown Adipose Tissue Metabolism Using Mirabegron	nan	COMPLETED
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide	nan	COMPLETED
Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADRA1B binder may also engage these)

Protein	Name	Similarity
P15823	—	1.000	P15823 →
P97717	—	1.000	P97717 →
P18841	—	0.996	P18841 →
P11615	—	0.996	P11615 →
Q91175	—	0.995	Q91175 →
P23944	—	0.993	P23944 →
P25115	—	0.992	P25115 →
Q9TTM9	—	0.992	Q9TTM9 →
P97714	—	0.992	P97714 →
Q28838	—	0.992	Q28838 →
ADRA1D	Alpha-1D adrenergic receptor	0.991	landscape →
P30545	—	0.991	P30545 →
Q6XXX9	—	0.991	Q6XXX9 →
P07700	—	0.990	P07700 →
P19328	—	0.990	P19328 →
Q6XXY0	—	0.990	Q6XXY0 →
Q8BLD9	—	0.990	Q8BLD9 →
O77715	—	0.990	O77715 →
O77713	—	0.989	O77713 →
O19025	—	0.989	O19025 →
DRD5	D(1B) dopamine receptor	0.989	landscape →
P18901	—	0.989	P18901 →
O19012	—	0.989	O19012 →
O19032	—	0.988	O19032 →
Q60475	—	0.988	Q60475 →
Q28997	—	0.988	Q28997 →
Q25322	—	0.988	Q25322 →
Q5IS72	—	0.988	Q5IS72 →
O77723	—	0.988	O77723 →
P19020	—	0.988	P19020 →