SCHEMBL1387500

SCHEMBL1387500

O=C(NC1c2ccccc2-c2[nH]c(=O)c3nccn3c21)c1cccnc1

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
STK33 Q9BYT3 1/20 0.41
HSP90AB1 P08238 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1387973 0.91
SCHEMBL1388119 0.84
SCHEMBL1388045 0.81
SCHEMBL1387813 0.79 PDE2A (0.43)
SCHEMBL1387540 0.78 PDE2A (0.42)
SCHEMBL7417663 0.78
SCHEMBL1388060 0.76 GSK3B (0.45)
SCHEMBL7848141 0.76
SCHEMBL1387638 0.75 RXFP1 (0.41)
SCHEMBL1387844 0.74 PDE2A (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2002539162-A 2002-11-19 JP claimed
EP-1161238-A1 AMYOTROPIC LATERAL SCLEROSIS TREATMENT WITH A COMBINATION OF RILUZOLE AND AN AMPA RECEPTOR ANTAGONIST Aventis Pharma S.A. (FR) 2001-12-12 EP claimed
EP-0752992-B1 IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AVENTIS PHARMA SA (FR) 2001-05-30 EP claimed
WO-2000054772-A1 AMYOTROPIC LATERAL SCLEROSIS TREATMENT WITH A COMBINATION OF RILUZOLE AND AN AMPA RECEPTOR ANTAGONIST AVENTIS PHARMA S.A. (FR) 2000-09-21 WO claimed
US-5807859-A ANTIISCHEMIC AGENTS; BRAIN DISORDERS RHONE-POULENC RORER S.A. (FR) 1998-09-15 US claimed
JP-H09510727-A 1997-10-28 JP claimed
EP-0752992-A1 IMIDAZO(1,2-A)INDENO(1,2-E)PYRAZINE-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Aventis Pharma S.A. (FR) 1997-01-15 EP claimed
WO-1995026350-A1 IMIDAZO(1,2-A)INDENO(1,2-E)PYRAZINE-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1995-10-05 WO claimed
EP-1161238-A1 AMYOTROPIC LATERAL SCLEROSIS TREATMENT WITH A COMBINATION OF RILUZOLE AND AN AMPA RECEPTOR ANTAGONIST Aventis Pharma S.A. (FR) 2001-12-12 EP disclosed
EP-0752992-B1 IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AVENTIS PHARMA SA (FR) 2001-05-30 EP disclosed
WO-2000054772-A1 AMYOTROPIC LATERAL SCLEROSIS TREATMENT WITH A COMBINATION OF RILUZOLE AND AN AMPA RECEPTOR ANTAGONIST AVENTIS PHARMA S.A. (FR) 2000-09-21 WO disclosed
US-5807859-A ANTIISCHEMIC AGENTS; BRAIN DISORDERS RHONE-POULENC RORER S.A. (FR) 1998-09-15 US disclosed
EP-0752992-A1 IMIDAZO(1,2-A)INDENO(1,2-E)PYRAZINE-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Aventis Pharma S.A. (FR) 1997-01-15 EP disclosed
WO-1995026350-A1 IMIDAZO(1,2-A)INDENO(1,2-E)PYRAZINE-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1995-10-05 WO disclosed