Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimegestone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 8/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 11/20 | 0.58 |
| ▸ | AR | P10275 | 5/20 | 0.58 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimegestone SCHEMBL518768 | 1.00 | PGR (0.72) | PGRNR3C1ARNR3C2CYP3A4 | |
| Trimegestone SCHEMBL17906556 | 1.00 | PGR (0.72) | PGRNR3C1ARNR3C2CYP3A4 | |
| Trimegestone SCHEMBL3691258 | 1.00 | PGR (0.72) | PGRNR3C1ARNR3C2CYP3A4 | |
| Trimegestone SCHEMBL6847373 | 1.00 | PGR (0.72) | PGRNR3C1ARNR3C2CYP3A4 | |
| Trimegestone SCHEMBL13752884 | 1.00 | PGR (0.72) | PGRNR3C1ARNR3C2CYP3A4 | |
| Trimegestone SCHEMBL3155792 | 1.00 | PGR (0.72) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL19286040 | 0.93 | PGR (0.74) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL21231223 | 0.90 | PGR (0.70) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL13875044 | 0.90 | PGR (0.70) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL20952986 | 0.89 | PGR (0.68) | PGRNR3C1ARNR3C2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10624903-B2 | Longer-acting progestin prodrug contraceptives | EVESTRA, INC. (US) | 2020-04-21 | — | — | US | disclosed |
| US-20190117670-A1 | LONGER-ACTING PROGESTIN PRODRUG CONTRACEPTIVES | EVESTRA, INC. | 2019-04-25 | — | — | US | disclosed |
| WO-2009043577-A2 | CONTRACEPTIVE 19-NOR PROGESTERONES | Grünenthal GmbH (DE) | 2009-04-09 | — | — | WO | disclosed |
| US-20090093448-A1 | 19-NOR-PROGESTERONE FOR CONTRACEPTION | GRUNENTHAL GMBH (DE) | 2009-04-09 | — | — | US | disclosed |
| US-20090093448-A1 | 19-NOR-PROGESTERONE FOR CONTRACEPTION | GRUNENTHAL GMBH (DE) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117670-A1 | LONGER-ACTING PROGESTIN PRODRUG CONTRACEPTIVES | CYP19A1, PGR, GNRHR | PGR 2/4885NR3C1 115/4885AR 242/4885 |
| US-20090093448-A1 | 19-NOR-PROGESTERONE FOR CONTRACEPTION | CYP19A1, CYP17A1, HSD17B11 | PGR 7/4885NR3C1 149/4885AR 339/4885 |
| US-10624903-B2 | Longer-acting progestin prodrug contraceptives | CYP19A1, PGR, GNRHR | PGR 2/4885NR3C1 115/4885AR 242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.